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KMID : 0043319940170060438
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Archives of Pharmacal Research
1994 Volume.17 No. 6 p.438 ~ p.442
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Antimicrobial Activity of Ganoderma lucidum Extrct Alone and in Combination withSsome Antibiotics
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Yoon Sang-Yeon
Eo Seong-Kug
Kim Young-So
Lee Chong-Kil
Han Seong -Sun
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Abstract
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Antimicrobial activity of GL (the aqueous extract from the carpophores of Ganoderma lucidum () was tested in vitro aginst Gram positive and Gram negative bacteria by serial broth dilution method, and the antimicrobial activity was expressed by minimal inhibitory concentration (MIC). Among fifteeen species of bacteria tested, the natimicrobial activity of GL was of antimicrobial combinations of GL with four kinds of antibiotics (ampicilin, cefazolin, oxytet-racycline and chloramphenicol), the fractional inhibitory concentraction index (FICI) was determined by checkerboard assy for each stain. The antimicrobial combinations of GL with four antibiotics resulted in additive effect in most instances, synergism in two instances, and antagonism in two instances. Synergism was obversed when GL was combined with cefazolin against Bacillus subtilis and Klebsiella oxytoca.
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KEYWORD
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Ganoderma lucidum Carpophores, Antimicrobial activity, Minimal inhibitory concerntration(MIC), Checketboard assay, Fractional inhibitory concentartion index(FICI), Antimicrobial combinations
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